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Merck

CHRM2

cholinergic receptor, muscarinic 2

Synonyms:
HM2
Species:
Human CHRM2 (1129), Mouse Chrm2 (243764), Rat Chrm2 (81645), sheep CHRM2 (101102897), sheep CHRM2 (100628317), Domestic Rabbit CHRM2 (100342878), domestic guinea pig Chrm2 (100715343), naked mole-rat Chrm2 (101714286), chicken CHRM2 (418126), domestic cat CHRM2 (101099790) ...More
UniProtKB ID:
P08172, Q4VBK6, Q9P1X9
Gene ID:
  • Human(1129) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(243764) cholinergic receptor, muscarinic 2, cardiac
  • Rat(81645) cholinergic receptor, muscarinic 2
  • sheep(101102897) cholinergic receptor, muscarinic 2
  • sheep(100628317) cholinergic receptor, muscarinic 2
  • Domestic Rabbit(100342878) cholinergic receptor, muscarinic 2
  • domestic guinea pig(100715343) cholinergic receptor, muscarinic 2
  • naked mole-rat(101714286) cholinergic receptor, muscarinic 2
  • chicken(418126) cholinergic receptor, muscarinic 2
  • domestic cat(101099790) cholinergic receptor, muscarinic 2
  • cow(522170) cholinergic receptor, muscarinic 2
  • dog(403858) cholinergic receptor, muscarinic 2

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Small Molecule - Agonist

Product Number
Description
Species
O9126
Oxotremorine sesquifumarate salt, ≥98% (HPLC), solid,
Species
human
C011
cis-2-Methyl-5-trimethylammoniummethyl-1,3-oxathiolane iodide, ,
Species
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Species
human
O100
Oxotremorine M, solid,
Species
human
A2251
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
M105
Methoctramine hydrate, ≥97% (NMR), solid,
Species
human
O0288000
Oxybutynin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
BP701
Oxybutynin hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
O5015
Oxybutynin chloride, meets EP, USP testing specifications,
Species
human
SML1102
Darifenacin hydrobromide, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
WH0001129M1
Monoclonal Anti-CHRM2 antibody produced in mouse, clone 4B5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
AB9452
Anti-Muscarinic Acetylcholine Receptor M2 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
MAB367
Anti-Muscarinic Acetylcholine Receptor m2 Antibody, clone M2-2-B3, clone M2-2-B3, Chemicon®, from rat,
Species Reactivity
human, mammals, monkey, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
SAB4500245
Anti-CHRM2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
M272
Monoclonal Anti-Muscarinic Acetylcholine Receptor (M2) antibody produced in mouse, clone 31-1D1, ascites fluid,
Species Reactivity
human, mouse, pig, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Species
human
D4526
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Species
human
H1512
Haloperidol, powder,
Species
human, rat
51330
Harmaline, ≥95%,
Species
human, rat

Small Molecule - Ligand

Product Number
Description
Species
A138
Aminobenztropine, solid,
Species
human

Proteins

Product Number
Description
Species
HTS115M
ChemiSCREEN Membrane Preparation Recombinant Human M2 Muscarinic Acetylcholine Receptor, Human M2 GPCR membrane prepation for Radioligand binding Assays.,
Species
human