ATM
ataxia telangiectasia mutated
Synonyms:
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Species:
Human ATM (472), Mouse Atm (11920), Rat Atm (300711), Zebrafish atm (403064), cow ATM (526824), Horse ATM (100061765), domestic cat ATM (101089291), dog ATM (479450), chicken ATM (395401), Thale Cress ATM (823975) ...More
UniProtKB ID:
Gene ID:
- Human(472) Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Mouse(11920) ataxia telangiectasia mutated homolog (human)
- Rat(300711) ataxia telangiectasia mutated
- Zebrafish(403064) ataxia telangiectasia mutated
- cow(526824) ataxia telangiectasia mutated
- Horse(100061765) ataxia telangiectasia mutated
- domestic cat(101089291) ataxia telangiectasia mutated
- dog(479450) ataxia telangiectasia mutated
- chicken(395401) ataxia telangiectasia mutated
- Thale Cress(823975) serine/threonine-protein kinase ATM
- naked mole-rat(101718948) ataxia telangiectasia mutated
- domestic guinea pig(100717983) ataxia telangiectasia mutated
- sheep(101105847) ataxia telangiectasia mutated
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-p-ATM (Ser1981) Antibody, clone 1E19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Rabbit anti-ATM Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate, clone 10H11.E12, from mouse, PE,
Species Reactivity
human, mouse, rat
Application
flow cytometry
Anti-ATM Antibody, clone AM9, ascites fluid, clone AM9, Upstate®,
Species Reactivity
human
Application
western blot
Anti-ATM antibody, Mouse monoclonal, clone SYML6A10, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunocytochemistry
microarray
western blot
microarray
western blot
esiRNA
Product Number
Description
Species