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Merck

AIFM1

apoptosis-inducing factor, mitochondrion-associated, 1

Synonyms:
AIF, CMTX4, COWCK, COXPD6, PDCD8
Species:
Human AIFM1 (9131), Mouse Aifm1 (26926), Rat Aifm1 (83533), Zebrafish aifm1 (373125), cow AIFM1 (535714), Horse AIFM1 (100054546), domestic cat AIFM1 (768258), dog AIFM1 (481048), chicken AIFM1 (428688), naked mole-rat Aifm1 (101698690) ...More
UniProtKB ID:
O95831, A4QPB4, B1ALN1, B2RB08, D3DTE9, Q1L6K4, Q1L6K6, Q2QKE4
Gene ID:
  • Human(9131) Summary: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]
  • Mouse(26926) apoptosis-inducing factor, mitochondrion-associated 1
  • Rat(83533) apoptosis-inducing factor, mitochondrion-associated 1
  • Zebrafish(373125) apoptosis-inducing factor, mitochondrion-associated 1
  • cow(535714) apoptosis-inducing factor, mitochondrion-associated, 1
  • Horse(100054546) apoptosis-inducing factor, mitochondrion-associated, 1
  • domestic cat(768258) apoptosis-inducing factor, mitochondrion-associated, 1
  • dog(481048) apoptosis-inducing factor, mitochondrion-associated, 1
  • chicken(428688) apoptosis-inducing factor, mitochondrion-associated, 1
  • naked mole-rat(101698690) apoptosis-inducing factor, mitochondrion-associated, 1
  • domestic guinea pig(100730787) apoptosis-inducing factor, mitochondrion-associated, 1
  • sheep(101121574) apoptosis-inducing factor, mitochondrion-associated, 1
  • sheep(100188912) apoptosis-inducing factor, mitochondrion-associated, 1
  • Domestic Rabbit(100347778) apoptosis-inducing factor, mitochondrion-associated, 1

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Antibodies

Product Number
Description
Species Reactivity
Application
07-208
Anti-AIF (Apoptosis Inducing Factor) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
AB16501
Anti-AIF Antibody, internal domain, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
ZRB1849
Anti-AIF Antibody, clone 1E4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
A7549
Anti-Apoptosis-Inducing Factor antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
microarray
western blot