- Epimerization of benzylpenicilloic acid in alkaline media.
Epimerization of benzylpenicilloic acid in alkaline media.
Journal of pharmaceutical sciences (1984-01-01)
I Ghebre-Sellassie, S L Hem, A M Knevel
PMID6694069
ABSTRACT
5R,6R-Benzylpenicilloic acid was found to epimerize slowly in alkaline media to 5S,6R-benzylpenicilloic acid until equilibrium was established. Epimerization proceeded via the imine tautomer of penamaldic acid rather than the enamine form and was found to favor the 5S,6R-epimer at equilibrium. The conversion process was monitored using both reverse-phase high-performance liquid chromatography and NMR spectroscopy.
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