- Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice.
Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice.
Bulletin of experimental biology and medicine (2007-04-07)
E G Kuznetsova, T G Amstislavskaya, V V Bulygina, M A Tibeikina, N K Popova
PMID17415471
ABSTRACT
A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.
MATERIALS