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M7771

Sigma-Aldrich

N-Methoxysuccinyl-Ala-Ala-Pro-Met p-nitroanilide

>95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C27H38N6O9S
CAS Number:
70967-91-8
Molecular Weight:
622.69
MDL number:
MFCD00077134
UNSPSC Code:
12352202
PubChem Substance ID:
24897180

Assay

>95% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCSC)C(=O)Nc2ccc(cc2)N(=O)=O

InChI

1S/C27H38N6O9S/c1-16(28-22(34)11-12-23(35)42-3)24(36)29-17(2)27(39)32-14-5-6-21(32)26(38)31-20(13-15-43-4)25(37)30-18-7-9-19(10-8-18)33(40)41/h7-10,16-17,20-21H,5-6,11-15H2,1-4H3,(H,28,34)(H,29,36)(H,30,37)(H,31,38)

InChI key

LUUQUDLEABXXQL-UHFFFAOYSA-N

Gene Information

human ... CTSG(1511)
mouse ... CTSG(13035)
rat ... CTSG(290257)

Amino Acid Sequence

N-MeOSuc-Ala-Ala-Pro-Met-pNA

Substrates

Colorimetic substrate for cathepsin G.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.
K Nakajima et al.
The Journal of biological chemistry, 254(10), 4027-4032 (1979-05-25)
Jorge Frias et al.
Journal of microbiology and biotechnology, 31(2), 327-337 (2020-11-06)
Fibrinolytic enzymes with a direct mechanism of action and safer properties are currently requested for thrombolytic therapy. This paper reports on a new enzyme capable of degrading blood clots directly without impairing blood coagulation. This enzyme is also non-cytotoxic and

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