D8428
Decorin from bovine articular cartilage
salt-free, lyophilized powder
Synonym(s):
Decorin protein
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About This Item
Recommended Products
biological source
bovine articular cartilage
Quality Level
form
salt-free, lyophilized powder
mol wt
~100 kDa
packaging
glass bottle of 0.5 mg
technique(s)
cell culture | mammalian: suitable
solubility
PBS: ≥2.00 mg/mL, clear, colorless to yellow
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... DCN(280760)
General description
Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.
Application
Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.
Biochem/physiol Actions
Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.
Other Notes
Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA.
Pinto V V, et al.
PLoS ONE, 6(3), e17942-e17942 (2011)
Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan.
Scott P G, et al.
Proceedings of the National Academy of Sciences of the USA, 101(44), 15633-15638 (2004)
Daniela G Seidler et al.
IUBMB life, 60(11), 729-733 (2008-09-19)
A molecular network of extracellular matrix molecules determines the tissue architecture and accounts for mechanical properties like compressibility or stretch resistance. It is widely accepted that the elements of the cellular microenvironment are important regulators of the cellular behavior in
Xiaolei Wang et al.
Scientific reports, 7(1), 9672-9672 (2017-08-31)
Choroidal neovascularization(CNV) is the most severe complication in Age-related macular degeneration(AMD) and the most common cause of irreversible blindness in the elderly in developed world. The aim of this study was to identify the effect of transforming growth factor-β(TGF-β) and
Engineering of fibrillar decorin matrices for a tissue-engineered trachea.
Hinderer S, et al.
Biomaterials, 33(21), 5259-5266 (2012)
Articles
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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