STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
Synonyms:
D12S1644, IL-4-STAT, STAT6B, STAT6C
Species:
Human STAT6 (6778), Mouse Stat6 (20852), Rat Stat6 (362896), Zebrafish stat6 (337413), Horse STAT6 (100050053), domestic cat STAT6 (101089873), dog STAT6 (100142679), chicken STAT6 (100859196), cow STAT6 (353105), sheep STAT6 (101102134) ...More
UniProtKB ID:
Gene ID:
- Human(6778) Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- Mouse(20852) signal transducer and activator of transcription 6
- Rat(362896) signal transducer and activator of transcription 6, interleukin-4 induced
- Zebrafish(337413) signal transducer and activator of transcription 6, interleukin-4 induced
- Horse(100050053) signal transducer and activator of transcription 6, interleukin-4 induced
- domestic cat(101089873) signal transducer and activator of transcription 6, interleukin-4 induced
- dog(100142679) signal transducer and activator of transcription 6, interleukin-4 induced
- chicken(100859196) signal transducer and activator of transcription 6, interleukin-4 induced
- cow(353105) signal transducer and activator of transcription 6, interleukin-4 induced
- sheep(101102134) signal transducer and activator of transcription 6, interleukin-4 induced
- naked mole-rat(101725744) signal transducer and activator of transcription 6, interleukin-4 induced
- Domestic Rabbit(100344264) signal transducer and activator of transcription 6, interleukin-4 induced
- domestic guinea pig(100726686) signal transducer and activator of transcription 6, interleukin-4 induced
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Product Number
Description
Species
Phosphotyrosine STAT6 / Signal Transducer and Activator of Transcription 6 ELISA Kit, ,
Species
human
Cell-Based ELISA for detecting phospho-STAT6 (pTyr641) in cultured cell lines, 96 assays,
Species
mouse, human
Cell-Based phospho-STAT ELISA Samper Kit for detecting phospho-STAT1 (pTyr701), phospho-STAT3 (pTyr705), and phospho-STAT5 (pTyr694) in cultured cell lines, 192 assays,
Species
mouse, rat, human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-STAT6 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-STAT6 antibody produced in mouse, clone 4G7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-phospho-STAT6 (pThr645) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-STAT6 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-phospho-STAT6 (Tyr641) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse
Application
western blot
Proteins
Product Number
Description
Species
STAT6, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human