PLN
phospholamban
Synonyms:
CMD1P, CMH18, PLB
Species:
Human PLN (5350), Mouse Pln (18821), Rat Pln (64672), chicken PLN (396378), domestic cat PLN (101097897), dog PLN (414755), domestic guinea pig Pln (100721387), naked mole-rat Pln (101699885), Domestic Rabbit PLN (100009299), cow PLN (100125240)
UniProtKB ID:
Gene ID:
- Human(5350) Summary: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]
- Mouse(18821) phospholamban
- Rat(64672) phospholamban
- chicken(396378) phospholamban
- domestic cat(101097897) phospholamban
- dog(414755) phospholamban
- domestic guinea pig(100721387) phospholamban
- naked mole-rat(101699885) phospholamban
- Domestic Rabbit(100009299) phospholamban
- cow(100125240) phospholamban
- sheep(101102067) phospholamban
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PLB antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunofluorescence
Anti-phospho-PLB (pSer16+Thr17) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunofluorescence
Anti-PLN (N-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, human, pig, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospholamban Antibody, clone 4J16 , ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-Phospholamban (Ser16) Antibody, Upstate®, from rabbit,
Species Reactivity
bovine, canine, human, mouse, pig, rabbit, rat
Application
western blot
esiRNA
Product Number
Description
Species