ACTN4
actinin, alpha 4
Synonyms:
ACTININ-4, FSGS, FSGS1
Species:
Human ACTN4 (81), Mouse Actn4 (60595), Rat Actn4 (63836), Zebrafish actn4 (322221), cow ACTN4 (522269), domestic cat ACTN4 (101093978), dog ACTN4 (484526), chicken ACTN4 (396024), sheep ACTN4 (101111737), domestic guinea pig Actn4 (100733111)
UniProtKB ID:
Gene ID:
- Human(81) Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
- Mouse(60595) actinin alpha 4
- Rat(63836) actinin alpha 4
- Zebrafish(322221) actinin, alpha 4
- cow(522269) actinin, alpha 4
- domestic cat(101093978) actinin, alpha 4
- dog(484526) actinin, alpha 4
- chicken(396024) actinin, alpha 4
- sheep(101111737) actinin, alpha 4
- domestic guinea pig(100733111) actinin, alpha 4
- naked mole-rat(101710271) actinin, alpha 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ACTN4 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-Alpha Actinin-4 antibody, Rabbit Monoclonal, recombinant, expressed in HEK 293 cells, clone RM287, purified immunoglobulin,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-ACTN4 antibody produced in mouse, clone 4D10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-ACTN4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-ACTN4 antibody produced in mouse, clone 4D10, ascites fluid,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Proteins
Product Number
Description
Species
α-Actinin from chicken gizzard, ~80% α-actinin basis (SDS-PAGE), ammonium sulfate suspension,
Species
mouse, chicken, rat, human