ACLY
ATP citrate lyase
Synonyms:
ACL, ATPCL, CLATP
Species:
Human ACLY (47), Mouse Acly (104112), Rat Acly (24159), chicken ACLY (395373), Horse ACLY (100053195), cow ACLY (511135), domestic cat ACLY (100422779), dog ACLY (607852), naked mole-rat Acly (101700349), domestic guinea pig Acly (100714933)
UniProtKB ID:
Gene ID:
- Human(47) Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- Mouse(104112) ATP citrate lyase
- Rat(24159) ATP citrate lyase
- chicken(395373) ATP citrate lyase
- Horse(100053195) ATP citrate lyase
- cow(511135) ATP citrate lyase
- domestic cat(100422779) ATP citrate lyase
- dog(607852) ATP citrate lyase
- naked mole-rat(101700349) ATP citrate lyase
- domestic guinea pig(100714933) ATP citrate lyase
- sheep(654404) ATP citrate lyase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ATP-Citrate Lyase antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-ATP-Citrate Lyase (pSer454) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ACLY, clone 5F8D11 Antibody, clone 5F8D11, from mouse,
Species Reactivity
human, monkey, mouse
Application
ELISA
flow cytometry
immunofluorescence
immunohistochemistry
western blot
flow cytometry
immunofluorescence
immunohistochemistry
western blot
Anti-ATP-citrate synthase/ACLY Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, human, mouse, porcine, rat, sheep
Application
immunohistochemistry
western blot
western blot
Anti-ACLY Antibody, clone 8A0V0, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Proteins
Product Number
Description
Species
ATP Citrate Lyase Active human, recombinant, expressed in baculovirus, ≥90% (SDS-PAGE),
Species
human