Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering.

Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering.

Journal of bioscience and bioengineering (2010-06-15)

Junichiro Marui, Sumiko Ohashi-Kunihiro, Tomohiro Ando, Marie Nishimura, Hideaki Koike, Masayuki Machida

PMID20541108

摘要

Aspergillus oryzae penicillin biosynthetic genes were clustered. The penicillin production was positively regulated by VeA, a global gene regulator required for transcriptional expression of the penicillin biosynthetic genes. Overexpression of the biosynthetic genes by a strong promoter yielded a greater than 100-fold increase in penicillin production.

材料

货号

品牌

产品描述

P0389

Sigma-Aldrich

青霉素来源于蜡样芽胞杆菌, lyophilized powder, 1,500-3,000 units/mg protein (using benzylpenicillin)