Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.

Nature communications (2018-01-24)

Rahul P Bakshi, Lee M Tatham, Alison C Savage, Abhai K Tripathi, Godfree Mlambo, Matthew M Ippolito, Elizabeth Nenortas, Steve P Rannard, Andrew Owen, Theresa A Shapiro

PMID29358624

摘要

Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles that confers long-lived prophylaxis against Plasmodium berghei ANKA malaria in C57BL/6 mice. Protection is obtained at plasma concentrations above 200 ng ml

材料

货号

品牌

产品描述

P5556

Sigma-Aldrich

Poloxamer 188 溶液, 10%, sterile-filtered, BioReagent, suitable for insect cell culture