- Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.
Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.
Frontiers in pharmacology (2018-01-23)
Ahmed Hasbi, Melissa L Perreault, Maurice Y F Shen, Theresa Fan, Tuan Nguyen, Mohammed Alijaniaram, Tomek J Banasikowski, Anthony A Grace, Brian F O'Dowd, Paul J Fletcher, Susan R George
PMID29354053
摘要
A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using
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抗-D1 多巴胺受体抗体，大鼠单克隆抗体 大鼠抗, clone 1-1-F11 s.E6, purified from hybridoma cell culture
Sigma-Aldrich
抗-磷酸化ERK1（pThr202/ pTyr204）和ERK2（pThr185/ pTyr187） 兔抗, affinity isolated antibody, buffered aqueous solution