- A fission yeast cell-based system for multidrug resistant HIV-1 proteases.
A fission yeast cell-based system for multidrug resistant HIV-1 proteases.
Cell & bioscience (2017-01-18)
Zsigmond Benko, Dong Liang, Ge Li, Robert T Elder, Anindya Sarkar, Jun Takayama, Arun K Ghosh, Richard Y Zhao
PMID28096973
摘要
HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patient treatment is the emergence of multidrug resistant PRs ( Three The three clinically isolated
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