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  • The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals.

The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals.

The international journal of biochemistry & cell biology (2002-07-20)
Avery August, Angela Fischer, Shengli Hao, Cynthia Mueller, Melanie Ragin
摘要

ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view.

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Sigma-Aldrich
ITK (352-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution