Chiral Brønsted acid catalyzed enantioselective hydrophosphonylation of imines: asymmetric synthesis of alpha-amino phosphonates.

Chiral Brønsted acid catalyzed enantioselective hydrophosphonylation of imines: asymmetric synthesis of alpha-amino phosphonates.

Organic letters (2005-06-17)

Takahiko Akiyama, Hisashi Morita, Junji Itoh, Kohei Fuchibe

摘要

[reaction: see text] A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Brønsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. Alpha-amino phosphonates were obtained with good to high enantioselectivities.

材料

货号

品牌

产品描述

674605

Sigma-Aldrich

(R)-3,3′-双[3,5-双(三氟甲基)苯基]-1,1′-联萘-2,2′-二基磷酸氢酯, 95%