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Merck
  • Cross-couplings between benzylic and aryl halides "on water": synthesis of diarylmethanes.

Cross-couplings between benzylic and aryl halides "on water": synthesis of diarylmethanes.

Chemical communications (Cambridge, England) (2010-01-12)
Christophe Duplais, Arkady Krasovskiy, Alina Wattenberg, Bruce H Lipshutz
摘要

A remarkably simple entry to unsymmetrical diarylmethanes has been developed that relies on an in situ organozinc-mediated, palladium-catalyzed cross-coupling. Thus, by mixing a benzyl and aryl halide together in the presence of Zn metal and a Pd catalyst, diarylmethanes are formed at room temperature without assistance by a surfactant; hence, "on water".

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Sigma-Aldrich
4-溴苯甲酸乙酯, 98%
Sigma-Aldrich
3-甲氧基氯苄, 97%