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Merck
  • [Comparison of different G-CSF treatment effectiveness in experiments on irradiated mice].

[Comparison of different G-CSF treatment effectiveness in experiments on irradiated mice].

Radiatsionnaia biologiia, radioecologiia (2012-12-12)
L M Rozhdestvenskiĭ, R A Shchegoleva, Iu B Deshevoĭ, N I Lisina, B A Titov
摘要

In the experiments on F1 (CBA x C57BL) and BALB mice irradiated by 137Cs gamma-rays, preparations of unglycosilated G-SCF such as Neupogen and their domestic analogs Leucostim and Neupomax were investigated. The tests such as 9-day bone marrow cellularity (BMC) and endogenous CFUs, the neutrophile number restoration, the 30-day survival index have shown that all three preparations have an approximately equal effectiveness relating to acute radiation disease treatment and granulopoiesis stimulation after a 5-10 day consecutive administration following irradiation of mice at lethal and sublethal doses. We have come to the conclusion that Leucostim and Neupomax can be regarded as adequate substitutes for Neupogen.

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Filgrastim, European Pharmacopoeia (EP) Reference Standard
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5 mg
预计发货时间 2025年4月28日
US$635.25
25 mg
预计发货时间 2025年4月28日
US$2,432.10