- Correlation analysis in a set of X-benzyltrimethylammonium derivatives with antimuscarinic activity.
Correlation analysis in a set of X-benzyltrimethylammonium derivatives with antimuscarinic activity.
Il Farmaco; edizione scientifica (1987-06-01)
M De Amici, C De Micheli, P Pratesi, E Grana, M G Santagostino Barbone, B Cappello, C Silipo, A Vittoria
PMID3653389
摘要
The results of a pharmacological investigation on a series of meta-substituted benzyltrimethylammonium salts possessing an antimuscarinic activity are reported. Correlative analysis shows that the pharmacodynamic activity is a function of the hydrophobic-lipophilic parameter associated with the substituent.