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Merck

Copper-catalyzed C-H azidation of anilines under mild conditions.

Journal of the American Chemical Society (2012-11-08)
Conghui Tang, Ning Jiao
摘要

A novel and efficient copper-catalyzed azidation reaction of anilines via C-H activation has been developed. This method, in which the primary amine acts as a directing group by coordinating to the metal center, provides ortho azidation products regioselectively under mild conditions. This effective route for the synthesis of aryl azides is of great significance in view of the versatile reactivity of the azide products.

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Sigma-Aldrich
苯胺, ACS reagent, ≥99.5%
Sigma-Aldrich
苯胺 盐酸盐, ≥99%
Sigma-Aldrich
苯胺, ReagentPlus®, 99%
Sigma-Aldrich
苯胺-15N, 98 atom % 15N
Supelco
苯胺, analytical standard
Supelco
苯胺 溶液, certified reference material, 5000 μg/mL in methanol