- Isolation of urinary p-hydroxylated metabolites of mephentermine and phentermine in male Wistar rats.
Isolation of urinary p-hydroxylated metabolites of mephentermine and phentermine in male Wistar rats.
Xenobiotica; the fate of foreign compounds in biological systems (1990-07-01)
M A Mori, N Uy-Yu, K Sakai, M Inoue, T Miyahara, H Kozuka
PMID2238700
摘要
1. p-Hydroxymephentermine (p-hydroxy-MP) and p-hydroxyphentermine (p-hydroxy-Ph) were isolated as hydrochlorides from urine of male Wistar rats repeatedly dosed with mephentermine (MP). In addition, p-hydroxy-Ph was isolated as the hydrochloride from urine of the rats dosed with phentermine (Ph). 2. These results substantiate previous indications that p-hydroxylation of MP and Ph was a primary metabolic reaction in the rat.
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