- Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.
Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.
Chemical communications (Cambridge, England) (2010-08-03)
Adam D Moorhouse, Christian Spiteri, Pallavi Sharma, Mire Zloh, John E Moses
PMID20676418
摘要
hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.
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