Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.

Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.

Organic letters (2010-05-06)

Olga P Pereshivko, Vsevolod A Peshkov, Erik V Van der Eycken

PMID20441203

摘要

An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA(2) coupling) is described, giving access to secondary propargylamines.

材料

货号

品牌

产品描述

P50900

Sigma-Aldrich

炔丙基胺, 98%

P50919

Sigma-Aldrich

炔丙基胺盐酸盐, 95%