- On the nitrile effect in L-rhamnopyranosylation.
On the nitrile effect in L-rhamnopyranosylation.
Carbohydrate research (2006-04-29)
David Crich, Mitesh Patel
PMID16643872
摘要
It is shown that the use of 5% acetonitrile or propionitrile in dichloromethane functions to increase the beta-selectivity of a number of L-rhamnopyranosylation reactions conducted by the thioglycoside method with activation by the 1-benzenesulfinyl piperidine/trifluoromethanesulfonic anhydride couple. The use of more significant quantities of acetonitrile or propionitrile results in the formation of complex reaction mixtures containing little coupled product, but from which Ritter-type products can be isolated.