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Merck
  • Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.

Nature (1990-02-01)
X D Fu, T Maniatis
摘要

A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.