- Localized Intra-Cavitary Therapy to Drive Systemic Anti-Tumor Immunity.
Localized Intra-Cavitary Therapy to Drive Systemic Anti-Tumor Immunity.
Frontiers in immunology (2022-03-01)
Vera S Donnenberg, Patrick L Wagner, James D Luketich, David L Bartlett, Albert D Donnenberg
PMID35222439
摘要
Metastasis to the pleural and peritoneal cavities is a common terminal pathway for a wide variety of cancers. This article explores how these unique environments both promote aggressive tumor behavior and suppresses anti-tumor immunity, and ways in which local delivery of protein therapeutics can leverage the contained nature of these spaces to a therapeutic advantage, achieving high intra-cavital concentrations while minimizing systemic toxicity.