High-Throughput Screening
High-throughput 24-well plate
High-throughput screening (HTS) is a technique used to run many reactions simultaneously in parallel synthesis. Also known as high-throughput experimentation (HTE), this technique is especially useful for quick and efficient screening of compounds to find the ideal reactants for your reaction. High-throughput screening methods often use automated systems such as robotic plating systems, automated data collection/analysis, and computer programs to identify the potential reactants. HTS has revolutionized the drug discovery process and is used by pharmaceutical companies, academic institutions, and research laboratories to quickly identify new potential drug candidates.
We offer a variety of products to give researchers a one-stop shop for all their high throughput needs.
KitAlysis™- high-throughput screening kits
ChemBeads – catalyst coated glass beads designed for HTE to remove the issues with solid handling in automation
KitAlysis™ Screening Kits
The KitAlysis™ screening kit platform allows for 24 unique chemical reactions to be performed with ~100 mg of user-provided substrate. While utilizing the KitAlysis™ Benchtop Inertion Box, these reactions can be conducted in an inert atmosphere without the use of a glovebox. KitAlysis™ screening kits are available pre-plated for seven different reaction types:
KitAlysis™ starter kit
Base Screening – 11 bases, 2 vials of each, and 2 open vials for additional bases to be added at the chemist’s discretion to quickly and efficiently screen bases for cross-coupling reactions
Buchwald-Hartwig Amination Screening - 12 catalysts, 2 vials of each, for multiple base and solvent systems for quick screening of Buchwald-Hartwig C-N cross-coupling
Medium (5, 6, 7) Ring Closing Metathesis Screening - 6 catalysts, 4 vials of each, for quickly and efficient screening of 5, 6, and 7 membered ring forming reactions of two intramolecular terminal alkenes
Miyaura Borylation Screening - 6 catalysts, 4 vials of each, and 2 diboron compounds for favorable palladium-catalyzed borylation conditions
24 Pd Precatalyst Screening – 24 cross-coupling precatalysts allowing the researcher to narrow their selection to more specified kits
Copper C-N Cross-Coupling Screening – 6 catalysts, 4 vials of each, for multiple base and solvent systems for quick screening of Copper C-N cross-coupling reactions
Suzuki-Miyaura Cross-Coupling Screening –6 catalysts, 4 vials of each, for favorable cross-coupling conditions
ChemBeads catalyst-coated glass beads in red.
ChemBeads
ChemBeads are catalyst-coated glass beads used for separation and purification processes in high-throughput experimentation. These catalyst beads are ideal for automated screening methods because sub-milligram amounts of solids can be accurately weighed and dispensed robotically. In addition, ChemBeads can be measured volumetrically to eliminate wasted material. ChemBeads have a high surface area-to-volume ratio and uniform size and shape, which ensures that the separation process is consistent and efficient, leading to reliable results.
Related Resources
- PEPPSI™ Catalyst - Introduction, Advantages and Applications
Discover PEPPSI catalysts for cross-coupling reactions. Improve yield and versatility in organic synthesis with these popular catalysts
- A-Phos
Explore our profile of versatile ligand for cross-coupling reactions, enhancing catalyst efficiency and selectivity
- 2nd Generation Buchwald Precatalysts
Read up on the technical article for more information on 2nd generation Buchwald precatalysts for efficient cross-coupling reactions
- ChemBeads
Find out more on the Solid catalyst-coated glass beads for efficient cross-coupling reactions.
- KitAlysis™ C-N (Buchwald-Hartwig) High-Throughput Screening Kit
Unlock C-N bond formation with the C-N Kitalysis Kit on innovative cross-coupling solutions.
- KitAlysis™ Suzuki-Miyaura Cross-Coupling Reaction Screening Kit
Enhance your cross-coupling reactions with the S-M Kitalysis Kit. Read more on efficient S-M bond formation.
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