重組細胞
expressed in baculovirus infected Sf9 cells
品質等級
產品線
PRECISIO® Kinase
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
20-28 nmol/min·mg
分子量
~38 kDa
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... NTRK3(4916)
生化／生理作用
TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival. TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
外觀
Supplied in 50 mM sodium phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 2 mM DTT, and 25% glycerol.
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
Antonio Marchetti et al.
Human mutation, 29(5), 609-616 (2008-02-23)
The neurotrophic tyrosine receptor kinase (NTRK) family is potentially implicated in tumorigenesis and progression of several neoplastic diseases, including lung cancer. We investigated a large number of pulmonary neuroendocrine tumors (PNETs) and non-small cell lung carcinomas (NSCLCs) without morphological evidence
F Lamballe et al.
Cell, 66(5), 967-979 (1991-09-06)
We report the isolation and molecular characterization of trkC, a new member of the trk family of tyrosine protein kinase genes. trkC is preferentially expressed in the brain. In situ hybridization studies revealed trkC transcripts in the hippocampus, cerebral cortex
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