跳转至内容
Merck
所有图片(1)

Key Documents

SRP6330

Sigma-Aldrich

CD46 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

别名:

AHUS2, MCP, MIC10, Membrane cofactor protein isoform 14, TLX, TRA2.10

登录查看公司和协议定价


About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥85% (SDS-PAGE)

形狀

liquid

分子量

33.8 kDa (302 aa, 35-313 aa + His tag)

包裝

pkg of 100 μg

濃度

1 mg/mL

雜質

<1 EU/μg endotoxin (LAL test)

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... CD46(4179)

一般說明

Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

外觀

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Weixin Xiong et al.
Thrombosis and haemostasis, 117(2), 401-414 (2016-11-11)
We showed previously that reduced level of vasostatin-2 (VS-2) correlates to the presence and severity of coronary artery disease. In this study, we aimed to figure out the role of chromogranin A (CGA) derived VS-2 in the development of atherosclerosis
Maximilian Richter et al.
Molecular therapy. Methods & clinical development, 5, 16013-16013 (2016-04-14)
Rituximab is a mouse/human chimeric monoclonal antibody targeted toward CD20. It is efficient as first-line therapy of CD20-positive B-cell malignancies. However, a large fraction of treated patients relapse with rituximab-resistant disease. So far, only modest progress has been made in
Jian Du et al.
Veterinary microbiology, 195, 87-95 (2016-10-25)
The outbreak of Chinese Giant Salamander (Andrias davidianus, CGS) Iridovirus (CGSIV) caused massive death of CGSs. However, some CGSs with low level of CGSIV usually could survive. In our study, major capsid protein (MCP) DNA replicates of CGSIV in shedding
Shao-Yeh Lu et al.
Applied and environmental microbiology, 85(11) (2019-03-25)
Microcin PDI (MccPDI), a class IIa microcin that is produced by Escherichia coli strains 25 and 284, is known to inhibit foodborne pathogenic enterohemorrhagic E. coli serotypes O157:H7 and O26. Here we demonstrate that MccPDI can inhibit Shigella strains and
Sinan Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(5), 1305-1315 (2020-12-10)
We recently identified CD46 as a novel therapeutic target in prostate cancer. In this study, we developed a CD46-targeted PET radiopharmaceutical, [89Zr]DFO-YS5, and evaluated its performance for immunoPET imaging in murine prostate cancer models. [89Zr]DFO-YS5 was prepared and its in

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门