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品質等級
化驗
≥97% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C(C1=CC=CC=C1Br)NC2=NC=NC3=C2C4=C(CCCC4)S3
生化／生理作用
KL201 is a circadian clock modulator that lengthens a circadian period in cells and tissues. KL201 selectively regulate cryptochrome 1 (Cry1). It binds to FAD-binding pocket of CRY1 preventing interaction with FBXL3 and ubiquitin-dependent degradation.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Simon Miller et al.
Cell chemical biology, 27(9), 1192-1198 (2020-06-06)
Cryptochrome 1 (CRY1) and CRY2 are core regulators of the circadian clock, and the development of isoform-selective modulators is important for the elucidation of their redundant and distinct functions. Here, we report the identification and functional characterization of a small-molecule
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