SML1180

WWL229

≥98% (HPLC)

• 别名: 2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
• 经验公式（希尔记法）: C₁₆H₂₂N₂O₅
• CAS号: 1338575-28-2
• 分子量: 322.36
• 分類程式碼代碼: 12161501
• PubChem物質ID: 329825704
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: oil
• 顏色: colorless to light yellow
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
• InChI: 1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
• InChI 密鑰: XVBRVSAGMWRVCK-UHFFFAOYSA-N

说明

生化／生理作用

WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC₅₀ of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable