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Merck
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文件

SML1087

Sigma-Aldrich

马来酸舒马尼罗

≥98% (HPLC)

别名:

CID 9818479马来酸酯, PNU-95,666马来酸酯, （5R）-5,6-二氢-5-（甲基氨基）-4H-咪唑并[4,5,1-ij]喹啉-2（1H）-马来酸酯, （R）-5,6-二氢-5-（甲氨基）-4H-咪唑并[4,5,1-ij]喹啉-2（1H）-马来酸酯

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About This Item

经验公式（希尔记法）:
C11H13N3O · C4H4O4
CAS号:
179386-44-8
分子量:
319.31
MDL號碼:
MFCD09832637
分類程式碼代碼:
12352200
PubChem物質ID:
329825464
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D -22 to -32°, c = 1 in H2O

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 10 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

O=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O

InChI

1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1

InChI 密鑰

VOJRMYBBPKNLLI-ORHWHDKWSA-N

應用

苏马尼罗马来酸酯已被用作多巴胺2型受体（D2R）激动剂，用于研究其对大鼠空间学习和记忆的影响。

生化／生理作用

Sumanirole是一种高度选择性的强效多巴胺D2受体激动剂，可降低黑质致密部中的血浆催乳素水平和降低的多巴胺神经元放电速率。Sumanirole在帕金森病动物模型中可有效刺激运动活动。

特點和優勢

该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Matthew F Lazenka et al.
The Journal of pharmacology and experimental therapeutics, 362(1), 14-23 (2017-04-16)
Clinically significant pain often includes a decrease in both behavior and mesolimbic dopamine signaling. Indirect and/or direct dopamine receptor agonists may alleviate pain-related behavioral depression. To test this hypothesis, the present study compared effects of indirect and direct dopamine agonists
Dopamine type 1-and 2-like signaling in the modulation of spatial reference learning and memory
Feyissa D D, et al.
Behavioural Brain Research, 362, 173-180 (2019)
Anna Niewiarowska-Sendo et al.
Biochimica et biophysica acta, 1864(10), 1855-1866 (2017-08-02)
In recent years a wide range of studies have shown that G protein-coupled receptors modulate a variety of cell functions through the formation of dimers. For instance, there is growing evidence for the dimerization of bradykinin or dopamine receptors, both
L Lencesova et al.
Life sciences, 191, 186-194 (2017-10-22)
Haloperidol is an antipsychotic agent and acts as dopamine D2 receptor (D2R) antagonist, as a prototypical ligand of sigma1 receptors (Sig1R) and it increases expression of type 1 IP We used differentiated NG-108 cells and H9c2 cells. Gene expression, Western
Vindhya Nawaratne et al.
Frontiers in cellular neuroscience, 15, 681539-681539 (2021-09-14)
The dopamine 2 receptors (D2R) are G-protein coupled receptors expressed both in pre- and post-synaptic terminals that play an important role in mediating the physiological and behavioral effects of amphetamine (Amph). Previous studies have indicated that the effects of Amph
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