SML0294
ABL127
≥98% (HPLC)
别名:
(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester, (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate, CID24856225
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所有图片(1)
About This Item
经验公式（希尔记法）:
C17H20N2O5
CAS号:
分子量:
332.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
film
顏色
colorless
溶解度
DMSO: ≥5 mg/mL
儲存溫度
2-8°C
SMILES 字串
O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O
InChI
1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1
InChI 密鑰
ZRHWCAFAIHTQKD-KRWDZBQOSA-N
生化／生理作用
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Shunta Ikeda et al.
Journal of biochemistry, 168(6), 643-650 (2020-07-15)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stem cells with ability to self-replicate and differentiate into mesodermal derivatives, such as adipocytes and osteoblasts. BM-MSCs are a critical component of the tumour microenvironment. They support tumour progression by recruiting additional
Ryotaro Yabe et al.
FEBS open bio, 8(9), 1486-1496 (2018-09-07)
Reversible methyl-esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer and neurodegenerative disorders. Protein phosphatase methyl-esterase (PME-1) specifically catalyzes
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