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生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
ARG1-3, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~40 kDa
物種活性
rat, human, mouse
濃度
~1.0 mg/mL
技術
western blot: 2-4 μg/mL using whole extracts of rat or mouse liver.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ARG1(383)
一般說明
Monoclonal Anti-ARG1 (mouse IgG1 isotype) is derived from the hybridoma ARG1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Arginase (ARG)1 gene, codes for type I isoform of arginase. ARG1 is a cytosolic enzyme expressed predominantly in the liver as a component of the urea cycle.
免疫原
synthetic peptide corresponding to a sequence at the N-terminal region of human ARG1, conjugated to KLH. The corresponding sequence differs by 3 amino acids in mouse ARG1 and by 4 amino acids in rat ARG1.
應用
Monoclonal Anti-ARG1 antibody produced in mouse has been used in immunoblotting.
生化／生理作用
Arginase hydrolyzes arginine to ornithine and urea. Arginases have been implicated in many disease processes, including vascular diseases, pulmonary diseases, infectious diseases, immune cell dysfunction and cancer. Inherited deficiency of ARG1 enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Arginase: a critical regulator of nitric oxide synthesis and vascular function
Durante W, et al.
Clinical and Experimental Pharmacology & Physiology, 34(9), 906-911 (2007)
Arginase Deficiency (Argininemia) (2018)
Molecular regulation of urea cycle function by the liver glucocorticoid receptor
Okun JG, et al.
Molecular Metabolism, 4(10), 732-740 (2015)
Jacob Ø Rasmussen et al.
Oncology reports, 32(4), 1447-1450 (2014-07-23)
A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological
Rodrigo A Fraga-Silva et al.
The journal of sexual medicine, 11(5), 1173-1181 (2014-03-13)
Hypercholesterolemia is a prevalent risk factor for the development of erectile dysfunction (ED), mostly due to an increase in oxidative stress and impaired nitric oxide (NO) bioavailability within the penis. Arginase is an enzyme that shares the common substrate L-arginine
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