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一般說明
Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. Tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla, and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
免疫原
Peptide with sequence CVQDELDTLAHAL, from the C Terminus of the protein sequence according to NP_954986.2; NP_000351.2; NP_954987.2.
生化／生理作用
Tyrosine hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, which is involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD) and point mutation in the gene coding for TH leads to Segawa′s syndrome.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
The Journal of Biological Chemistry (1964)
Tyrosine hydroxylase and regulation of dopamine synthesis.
Archives of Biochemistry and Biophysics (2011)
A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome.
Ludecke B
Human Gene Therapy (1995)
The function of tyrosine hydroxylase in the normal and Parkinsonian brain.
CNS & Neurological Disorders Drug Targets (2012)
Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.
Nakashima A
Biochemical and Biophysical Research Communications (2011)
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