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Merck

PZ0016

Sigma-Aldrich

多非利特

≥98% (HPLC), powder, hERG channel blocker

别名:

N-[4-[2-[甲基[2-[4-[(甲磺酰基)氨基]苯氧基]乙基]氨基]乙基]苯基]甲磺酰胺, UK-68798

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About This Item

经验公式(希尔记法):
C19H27N3O5S2
分子量:
441.56
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

多非利特, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: >20 mg/mL

儲存溫度

room temp

SMILES 字串

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2

InChI

1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

InChI 密鑰

IXTMWRCNAAVVAI-UHFFFAOYSA-N

基因資訊

human ... KCNH2(3757)

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生化/生理作用

多非利特是一种III类抗心律不齐和 hERG 通道阻滞剂。多非利特可选择地阻止延迟整流钾离子流 (Ikr)的快速成分。

特點和優勢

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

象形圖

Health hazardEnvironment

訊號詞

Danger

危險聲明

危險分類

Aquatic Chronic 2 - Repr. 1B - STOT RE 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Hanne Elming et al.
Expert opinion on pharmacotherapy, 4(6), 973-985 (2003-06-05)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Mortality, and especially morbidity caused by AF, are major and growing health problems in the western world. AF is strongly associated with arterial hypertension, congestive heart failure, valvular heart disease, ischaemic
S Durdagi et al.
Current medicinal chemistry, 18(17), 2601-2611 (2011-05-17)
The binding of various molecules to integral membrane proteins with optimal affinity and specificity is central to normal function of cell. While membrane proteins represent about one third of the whole cell proteome, they are a majority of common drug
Thom R G Stams et al.
European journal of pharmacology, 672(1-3), 126-134 (2011-10-18)
The novel antiarrhythmic drug K201 (4-[3-{1-(4-benzyl)piperidinyl}propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine monohydrochloride) is currently in development for treatment of atrial fibrillation. K201 not only controls intracellular calcium release by the ryanodine receptors, but also possesses a ventricular action that might predispose to torsade de pointes
Daniel M Johnson et al.
Circulation. Arrhythmia and electrophysiology, 5(1), 201-209 (2011-11-15)
AZD1305 is an investigational antiarrhythmic agent for management of atrial fibrillation. It blocks various cardiac ion currents at different potencies and has atrial-predominant electrophysiological effects. We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic
Cardiovascular drugs. Dofetilide.
J P Mounsey et al.
Circulation, 102(21), 2665-2670 (2000-11-22)

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