M3755

髓鞘碱性蛋白豚鼠片段 68-82

≥97% (HPLC)

• 别名: des-Gly⁷⁷, des-His⁷⁸-Myelin Basic Protein Bovine fragment 68-84
• 经验公式（希尔记法）: C₇₁H₁₁₃N₂₃O₂₈
• CAS号: 98474-59-0
• 分子量: 1736.79
• MDL號碼: MFCD00076871
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24896869
• NACRES: NA.32

属性

• 品質等級: 200
• 化驗: ≥97% (HPLC)
• 儲存溫度: −20°C
• SMILES 字串: CC(C)CC(NC(=O)C(CO)NC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(O)=O
• InChI: 1S/C71H113N23O28/c1-33(2)25-44(90-65(116)46(30-95)82-54(103)29-81-57(108)36(73)26-34-10-12-35(98)13-11-34)69(120)94-24-6-9-49(94)68(119)88-41(16-20-52(76)101)61(112)83-37(7-3-4-22-72)58(109)92-47(31-96)66(117)86-39(14-18-50(74)99)60(111)84-38(8-5-23-80-71(78)79)59(110)93-48(32-97)67(118)87-40(15-19-51(75)100)62(113)89-43(28-56(106)107)64(115)85-42(17-21-55(104)105)63(114)91-45(70(121)122)27-53(77)102/h10-13,33,36-49,95-98H,3-9,14-32,72-73H2,1-2H3,(H2,74,99)(H2,75,100)(H2,76,101)(H2,77,102)(H,81,108)(H,82,103)(H,83,112)(H,84,111)(H,85,115)(H,86,117)(H,87,118)(H,88,119)(H,89,113)(H,90,116)(H,91,114)(H,92,109)(H,93,110)(H,104,105)(H,106,107)(H,121,122)(H4,78,79,80)
• InChI 密鑰: ROVJYNCPHLNVSO-UHFFFAOYSA-N

说明

Amino Acid Sequence

Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn

一般說明

Myelin Basic Protein (MBP) is the second most abundant protein available in the central nervous system (CNS) myelin. It belongs to the intrinsically disordered or conformationally adaptable protein family.

應用

Myelin Basic Protein Guinea Pig Fragment 68-82 has been used for lymphocyte activation in human blood samples. It has also been used as a component of the incomplete Freund′s adjuvant for the induction of autoimmune encephalomyelitis in rats.

生化／生理作用

Myelin Basic Protein (MBP) is known as an executive molecule of myelin as it is a structural protein that is required for the formation of central nervous system (CNS) myelin. It participates in the adhesion of the cytosolic surfaces of the multi-layered compact myelin. MBP binds with several polyanionic proteins such as tubulin, actin, clathrin, and Ca²⁺-calmodulin. It binds to several negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and plays a role in the adhesion of these surfaces in the multilayered myelin sheath.

Myelin basic protein fragment that induces experimental allergic encephalomyelitis.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)