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Key Documents

L7261

Sigma-Aldrich

脂多糖 来源于肠沙门氏菌 肠道血清型

purified by trichloroacetic acid extraction

别名:

LPS(脂多糖)

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About This Item

MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Salmonella enterica (Serotype typhimurium)

品質等級

形狀

lyophilized powder

純化經由

trichloroacetic acid extraction

雜質

1-10% Protein (Lowry)

顏色

white to faint yellow

溶解度

water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

運輸包裝

ambient

儲存溫度

2-8°C

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一般說明

本品为从鼠伤寒沙门氏菌中提取的 TCA。来源菌株为 ATCC 7823。该 LPS 血清型已被用于诱导大鼠和豚鼠的 NOS。

應用

脂多糖(LPS)是革兰氏阴性细菌细胞壁的特征组分。LPS及其脂质A部分通过Toll样受体4(TLR4)刺激先天免疫系统的细胞,Toll样受体 4是Toll样受体蛋白家族的成员,其识别常见的病原体相关分子模式(PAMP)。

生化/生理作用

脂多糖 (LPS) 位于膜的外层,并且在非包封的菌株中,其暴露于细胞表面。它们有助于外膜的完整性,并可保护细胞免受胆汁盐和亲脂性抗生素的作用。

準備報告

该产品可溶于水(5mg / ml)或细胞培养基(1mg / ml),产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后,在盐水中可获得更高浓度的溶液(20mg/ml),但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液,而水会产生均匀的混浊溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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