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品質等級
化驗
≥98% (HPLC)
形狀
solid
儲存條件
protect from light
顏色
off-white to gray-pink
溶解度
DMSO: >10 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI 密鑰
YMFNPBSZFWXMAD-UHFFFAOYSA-N
應用
JSH-23 已被用作一种核因子 κB（NF-κB）p65 抑制剂。
生化／生理作用
JSH-23 是一种 NF-κB 核易位抑制剂。EMSA 和蛋白质印迹分析表明，它抑制 LPS 和细胞因子诱导的 NF-kB p65 亚基的核易位过程。该化合物具有适度的抑制活性（RAW 264.7 细胞中 IC50 值为 7.1 uM），但不影响 IkB 降解或恢复。该化合物以剂量依赖性方式抑制 LPS 诱导的细胞因子、COX2 和 iNOS 的表达，并且可能结合或干扰 p65 的和定位信号（NLS）。
其他說明
光和空气敏感。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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