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生物源
bovine kidney
品質等級
描述
Minimum 50 ng protein/vial by Bradford
形狀
aqueous solution
比活性
~17,000 units/mg protein
分子量
36 kDa
運輸包裝
dry ice
儲存溫度
−70°C
生化／生理作用
This enzyme phosphorylates and inactivates protein phosphatase 2A. The funtion appears to be related to the catalytic domain of p21-activated p65(PAK) protein kinase which is produced in apoptotic cells. AK is also involved in cytoskeleton organization and other signal transduction processes.
單位定義
One unit is the amount of enzyme that will incorporate 1 nmole of phosphoryl groups using myelin basic protein as a substrate per minute at pH 7 at 30 deg C.
外觀
50 ng per vial in 10 μl of 50 mM Tris-HCl, pH 7.0, containing 14 mM β-Mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, 65% ethyleneglycol, and 0.1% Brij® 35.
法律資訊
Brij is a registered trademark of Croda International PLC
儲存類別代碼
10 - Combustible liquids
Yadong Fan et al.
Frontiers in immunology, 13, 959495-959495 (2022-08-16)
Macrophages are involved in hepatocyte steatosis and necroinflammation and play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Impaired autophagy function (decreased autophagy or blocked autophagic flow) leads to cell damage and death and promotes NAFLD
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