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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~105 kDa
物種活性
human
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
技術
western blot: 0.5-1 μg/mL using HEK-293T cells expressing human ApoER2
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LRP8(7804)
一般說明
Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) is expressed predominantly in the brain and placenta. This gene is located on human chromosome 1p32.
The low-density lipoprotein receptor-related protein 8 (LRP8) or ApoER2 is a member of the LDL receptor family which includes LDLR and VLDLR. These proteins are involved in the uptake of lipid rich proteins into cells and cell signaling. ApoER2 assists in endocytosis and signal transduction.
特異性
Rabbit anti-ApoER2 antibody recognizes human ApoER2 by immunoblotting (approx. 105kDa). Staining of the ApoER2 band in immunoblotting is specifically inhibited by the ApoER2 immunizing peptide.
免疫原
synthetic peptide corresponding to amino acids 928-945 located near the C-terminus of human ApoER2, conjugated to KLH. This sequence is identical in mouse ApoER2.
應用
Anti-ApoER2 antibody produced in rabbit has been used in western blot analysis.
生化／生理作用
Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) play an important role in the endocytosis of plasma lipoproteins, including ApoE and cholesterol metabolism. In the central nervous system, ApoER2 mediates various neuronal signaling mechanisms during neuronal development, affecting neurite outgrowth, synapse formation and neuronal migration, and neuronal survival in response to acute damage. ApoER2 plays a central role in the reelin/Dab1 signaling pathway that controls neuronal positioning during brain development as well as long-term potentiation (LTP) in the adult brain.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Structural basis for ligand capture and release by the endocytic receptor ApoER2
Hirai H, et al.
EMBO Reports, 18(6), 982-999 (2017)
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
Beffert U, et al.
Neuron, 47(4), 567-579 (2005)
The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor
Dlugosz P and Nimpf J
International Journal of Molecular Sciences, 19(10), 3090-3090 (2018)
Further evidence for the association between LRP8 and schizophrenia
Xiao X, et al.
Schizophrenia Research (2017)
Jorge A Larios et al.
BMC neuroscience, 15, 108-108 (2014-09-23)
ApoER2 and the neurotrophin receptors Trk and p75(NTR) are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 and p75(NTR) are processed by metalloproteinases, followed by
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