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化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
protect from light
顏色
white to off-white
溶解度
H2O: >10 mg/mL
儲存溫度
−20°C
SMILES 字串
O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4
InChI
1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1
InChI 密鑰
KNACNUUSUYTFDY-LIWDBWMRSA-N
基因資訊
human ... DRD1(1812)
生化／生理作用
Potent, orally active D1 dopamine receptor agonist.
特點和優勢
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.
法律資訊
Manufactured and sold under exclusive license from Abbott Laboratories.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
L A Smith et al.
Journal of neural transmission (Vienna, Austria : 1996), 109(2), 123-140 (2002-06-22)
The potent and long acting D-1 receptor agonist, A-77636 reverses motor deficits in MPTP treated common marmosets following subcutaneous or oral administration. We now explore the effects of acute versus repeated administration of A-77636 and the relative roles of D-1
J Grider et al.
European journal of pharmacology, 342(2-3), 281-284 (1998-04-21)
The aim of the present study was to determine whether dopamine affects NaCl reabsorption in the medullary thick ascending limb of the loop of Henle. Basolateral dopamine (10(-6) M) significantly inhibited Cl- reabsorption in the in vitro microperfused rat medullary
P J Blanchet et al.
European journal of pharmacology, 309(1), 13-20 (1996-08-01)
The motor effects of dopamine D1 receptor activation and the optimal way to stimulate these receptors were studied in a primate model of parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), using 2 selective full dopamine D1 receptor agonists: A-77636 ([1
E Acquas et al.
The Journal of pharmacology and experimental therapeutics, 281(1), 360-368 (1997-04-01)
The role of dopamine (DA) D1 receptors in the regulation of acetylcholine (ACh) release in the striatum was studied using in vivo microdialysis in freely moving rats. Systemic administration of the full D1 DA receptor agonist A-77636 (4 micromol/kg) increased
D Wirtshafter et al.
Brain research, 750(1-2), 245-250 (1997-03-07)
We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists
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