生物源
synthetic (organic)
化驗
>95% (HPLC)
形狀
powder
分子量
Mw 428.5
溶解度
DMSO: 10 mg/mL, clear, colorless to greenish-yellow
儲存溫度
−20°C
InChI
1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
InChI 密鑰
BOZRFEQDOFSZBV-DHIUTWEWSA-N
應用
A922500 已用于抑制上皮人乳腺癌细胞系（MDA-MB-231）、毛地黄皂苷透化的人癌细胞、人肌管和巨噬细胞中的二酰基甘油酰基转移酶（DGAT）。
生化／生理作用
二酰基甘油酰基转移酶（DGAT-1）抑制剂； IC50 7 至 24 nM
二酰基甘油酰基转移酶（DGAT）1 抑制剂 A922500 在 0.03、0.3 和 3 mg/kg 浓度下可有效降低啮齿动物的餐后血清甘油三酯水平。这些结果表明 A922500 可能有助于降低心血管疾病风险。
外觀
A922500 以结晶固体形式提供。
準備報告
储备溶液可以通过将 A922500 溶解在所选溶剂中来制备。A922500 可溶于乙醇、DMSO 和二甲基甲酰胺（DMF）等有机溶剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Lovsletten NG, et al.
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A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program
Giudetti AM, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(3), 344-357 (2019)
Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
Jarc E, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(3), 247-265 (2018)
Andrew J King et al.
European journal of pharmacology, 637(1-3), 155-161 (2010-04-14)
Postprandial serum triglyceride concentrations have recently been identified as a major, independent risk factor for future cardiovascular events. As a result, postprandial hyperlipidemia has emerged as a potential therapeutic target. The purpose of this study was two-fold. Firstly, to describe
A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis
Leiguez E, et al.
Mediators of Inflammation, 2018 (2018)
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