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Merck

77140

Sigma-Aldrich

肽聚糖 来源于金黄色葡萄球菌

cell wall component

别名:

Peptidoglycan from S. aureus

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About This Item

MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.32

形狀

lyophilized powder

溶解度

soluble, hazy to turbid, colorless to faintly yellow

儲存溫度

−20°C

應用

金黄色葡萄球菌来源肽聚糖用于:
  • 刺激淋巴细胞:肽聚糖激活Toll样受体2 (TLR2),存在于哺乳动物细胞中。它作为聚肌胞的拮抗剂
  • 用于通过腹腔接种至单独样本刺激g型溶菌酶
  • 用在磷酸盐缓冲液中并注射到露斯塔野鲮鱼中,进而研究其对核苷酸结合的寡聚化结构域-2 (NOD-2)基因表达的影响

生化/生理作用

革兰氏阳性细菌的细胞壁主要由肽聚糖组成。它由肽桥互相连接的多糖链组成。这种肽聚糖使细胞壁具有一定的刚性,并使细胞具有机械强度。它是一种表面分子,能够刺激免疫反应,包括导致发热的细胞因子。

包裝

无底玻璃瓶。内容物在插入式融锥内。

其他說明

革兰氏阳性菌细胞壁的主要成分。由N-乙酰-D-葡糖胺和胞壁酸残基以β 1-4糖苷键交替相连形成的聚糖骨架组成。细菌肽聚糖的免疫活性;细菌细胞壁的肽聚糖类型及其分类学意义;在葡萄球菌感染期间对肽聚糖的抗体反应。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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L J Wheat et al.
The Journal of infectious diseases, 147(1), 16-22 (1983-01-01)
Levels of antibodies to peptidoglycan were measured by solid-phase radioimmunoassay in 76 patients with Staphylococcus aureus infections and 44 patients with infections caused by other bacteria. Levels of IgM antibodies to peptidoglycan were elevated in 24% of the patients with
The immunological activities of bacterial peptidoglycans.
D E Stewart-Tull
Annual review of microbiology, 34, 311-340 (1980-01-01)
Genomic characterization, phylogeny and gene regulation of g-type lysozyme in sole (Solea senegalensis)
Ponce M, et al.
Fish & Shellfish Immunology, 31(6), 925-937 (2011)
Xue Kong et al.
Frontiers in physiology, 9, 1476-1476 (2018-11-09)
Vesicomyidae clams are common species living in cold seeps, which incorporates symbiotic bacteria into their body maintaining endosymbiosis relationship. As members of pattern recognition receptor (PRR) family, peptidoglycan recognition proteins (PGRPs) recognize pathogen associated molecular patterns and play an important
A peptidoglycan recognition protein in innate immunity conserved from insects to humans
Kang D, et al.
Proceedings of the National Academy of Sciences of the USA, 95(17), 10078-10082 (1998)

商品

The basic structure of peptidoglycan (PGN) contains a carbohydrate backbone of alternating units of N-acetylglucosamine (GlcNAc) and Nacetylmuramic acid, with the N-acetylmuramic acid residues cross-linked to peptides.

Peptidoglycans

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