16866

单乙基甘氨酸二甲胺

analytical standard

• 别名: MEGX, MGEX, Monoethylglycinexylidide, N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide, Norlidocaine
• 经验公式（希尔记法）: C₁₂H₁₈N₂O
• CAS号: 7728-40-7
• 分子量: 206.28
• MDL號碼: MFCD00098991
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329751403
• NACRES: NA.24

属性

• 等級: analytical standard
• 品質等級: 100
• 化驗: ≥98.0% (HPLC)
• 儲存期限: limited shelf life, expiry date on the label
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 應用: pharmaceutical
• 格式: neat
• SMILES 字串: CC1=C(NC(CNCC)=O)C(C)=CC=C1
• InChI: 1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
• InChI 密鑰: WRMRXPASUROZGT-UHFFFAOYSA-N

说明

應用

• Pharmacokinetic Analysis: A study by Liu ZY et al. examines the pharmacokinetics of intravenous and topical lidocaine in patients undergoing thoracoscopic pulmonary resection. This research, which could integrate compounds like Monoethylglycinexylidine for analytical validation, highlights the importance of understanding drug dynamics for improving surgical outcomes (Liu et al., 2024).


• Veterinary Pharmacology: Knych HK et al. explore the pharmacokinetics and metabolism of lidocaine in horses following a palmar digital nerve block. Studies like this could benefit from the use of Monoethylglycinexylidine as a standard for accurate drug measurement and monitoring in veterinary medicine, ensuring safe and effective dosing (Knych et al., 2023).


• Anesthesia Research: Crouch CE et al. provide insights into the pharmacokinetics of lidocaine intraoperative infusion during partial hepatectomy for living liver donation. Research utilizing Monoethylglycinexylidine could enhance the understanding of local anesthetics′ systemic effects, contributing to safer anesthetic practices (Crouch et al., 2023).


• Anesthetic Efficacy in Avian Species: Escobar A et al. investigate the effects of two continuous infusion doses of lidocaine on isoflurane minimum anesthetic concentration in chickens. Incorporating Monoethylglycinexylidine in such studies could refine our understanding of dose-dependent effects and optimize anesthetic protocols for non-mammalian species (Escobar et al., 2023).


• Clinical Pharmacokinetics: Jin Y et al. discuss the simultaneous determination of lidocaine and its active metabolites in plasma by UPLC-MS/MS, applied to a clinical pharmacokinetic study in liver cancer patients. Monoethylglycinexylidine could be used to validate and calibrate assays, enhancing the reliability of pharmacokinetic data in clinical settings (Jin et al., 2022).

生化／生理作用

Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P301 + P310
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable