product name
巴弗洛霉素A1, InSolution, ≥90%, A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase
品質等級
化驗
≥90% (HPLC)
形狀
liquid
儲存期限
2 yr
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
儲存溫度
−20°C
InChI
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI 密鑰
XDHNQDDQEHDUTM-JQWOJBOSSA-N
一般說明
一种大环内酯类抗生素，可作为液泡型H+-ATP酶（V型；Ki=0.5 nM）的特异性抑制剂，是区分不同类型ATP酶的有价值的工具。据报告，可选择性地抑制β-分泌酶，这是一种参与淀粉样蛋白前体蛋白（APP）加工的酶。阻断巨噬细胞中的溶酶体胆固醇运输。已知会干扰脑细胞中的pH值调节。抑制体内和体外的骨吸收。在细胞活率测定中，已对多种细胞系具有细胞毒性作用。
生化／生理作用
主要靶标
液泡型H+-ATP酶
液泡型H+-ATP酶
细胞可渗透性：具有
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
初次融化后，等分并冷冻（-20°C）。等分试样在-20°C下可稳定保存1年。仅使用新鲜的DMSO进行进一步稀释。
其他說明
Sinha, S., and Lieberburg, I. 1999.Proc.Natl.Acad.Sci. USA96, 11049.
Calvert, C.M., and Sanders, D. 1995.J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995.Biochem.Biophys.Res. Commun.269, 255.
Crider, B.P., et al. 1994.J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994.J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994.J. Bone Miner.Res.9, 1575.
Drose, S., et al. 1993.Biochemistry32, 3902.
Furuchi, T., et al. 1993.J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988.Proc.Natl.Acad.Sci. USA85, 7972.
Calvert, C.M., and Sanders, D. 1995.J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995.Biochem.Biophys.Res. Commun.269, 255.
Crider, B.P., et al. 1994.J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994.J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994.J. Bone Miner.Res.9, 1575.
Drose, S., et al. 1993.Biochemistry32, 3902.
Furuchi, T., et al. 1993.J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988.Proc.Natl.Acad.Sci. USA85, 7972.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
188.6 °F - (refers to pure substance)
閃點（°C）
87 °C - (refers to pure substance)
其他客户在看
S Sinha et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(20), 11049-11053 (1999-09-29)
The major constituent of senile plaques in Alzheimer's disease is a 42-aa peptide, referred to as beta-amyloid (Abeta). Abeta is generated from a family of differentially spliced, type-1 transmembrane domain (TM)-containing proteins, called APP, by endoproteolytic processing. The major, relatively
K T Sundquist et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 9(10), 1575-1582 (1994-10-01)
It has been shown that a specific inhibitor of vacuolar H(+)-ATPases, bafilomycin A1, inhibits bone resorption by isolated chicken osteoclasts by blocking the proton pump in the ruffled border membrane. We report here the effects of bafilomycin A1 on bone
B P Crider et al.
The Journal of biological chemistry, 269(26), 17379-17381 (1994-07-01)
Vacuolar-type proton-translocating ATPases are complex heterooligomers that are characterized by a specific inhibition by bafilomycin A1. These enzymes have a peripheral ATP hydrolytic domain as well as a transmembranous sector. The transmembranous sector has been isolated by glycerol gradient centrifugation
T Furuchi et al.
The Journal of biological chemistry, 268(36), 27345-27348 (1993-12-25)
Certain steroids having an oxo group at the C-17 or C-20 position such as pregnenolone and dehydroisoandrosterone inhibit the cholesterol transport from lysosomes to other cellular sites. Taking advantage of the fact that the inhibition is reversed upon removal of
H Palokangas et al.
The Journal of biological chemistry, 269(26), 17577-17585 (1994-07-01)
Bafilomycin A1 (Baf), a specific inhibitor of the vacuolar-type proton pump, inhibited the entry of Semliki Forest virus and vesicular stomatitis virus into BHK-21 cells. The inhibition occurred at concentrations that dissipated intracellular acidic compartments. Viral infection was totally inhibited
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