5.06125

Paroxetine Hydrochloride

• 别名: Paroxetine Hydrochloride, 5-HT transporter, Paroxetine, Paxil
• 经验公式（希尔记法）: C₁₉H₂₀FNO₃ · xHCl
• CAS号: 110429-35-1
• 分子量: 329.37 (free base basis)
• 分類程式碼代碼: 12352200

属性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 0.065 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: soluble
• 儲存溫度: 2-8°C
• InChI: 1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
• InChI 密鑰: AHOUBRCZNHFOSL-YOEHRIQHSA-N

说明

一般說明

A very potent uptake inhibitor highly selective for 5-HT transporter (K_i = 0.065 nM and 0.05 nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms.

生化／生理作用

Primary Target
5-HT Uptake Transporter

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Brittain, G., et al. 2012. Profiles of drug substances, excipients, and related methodology.38, 407.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302 - H317 - H319 - H411
• 防範說明: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable