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Merck
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Key Documents

475880

Sigma-Aldrich

盐酸 ML-7-CAS 110448-33-4-Calbiochem

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

别名:

ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl

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About This Item

经验公式（希尔记法）:
C15H17IN2O2S · xHCl
CAS号:
110448-33-4
分子量:
416.28 (free base basis)
MDL號碼:
MFCD00065524
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

>98% (TLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

顏色

white

溶解度

50% ethanol: 4.5 mg/mL
DMSO: 4.5 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2

InChI 密鑰

GEHJIACZUFWBTK-UHFFFAOYSA-N

一般說明

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.

生化／生理作用

Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Product competes with ATP.
Reversible: yes
Target Ki: 300 nM against myosin light chain kinase

警告

Toxicity: Standard Handling (A)

準備報告

Further dilute with aqueous buffer just prior to use.

重構

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他說明

Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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