437725

Lipoxin A₄, 15-epi

Lipoxin A₄, 15-epi, CAS 171030-11-8, is an epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4.

• 别名: Lipoxin A₄, 15-epi, LXA₄-15-epi, 15( R)-LXA₄, Aspirin-triggered LXA₄, (5 S,6 R,15 R)-5,6,15-Trihydroxy-7,9,13- trans-11- cis-eicosatetraenoic acid, LXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
• 经验公式（希尔记法）: C₂₀H₃₂O₅
• CAS号: 171030-11-8
• 分子量: 352.47
• 分類程式碼代碼: 12352211
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 運輸包裝: wet ice
• 儲存溫度: −70°C
• InChI: 1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4+,7-5+,13-9+,14-10+
• InChI 密鑰: IXAQOQZEOGMIQS-CRSXNMAESA-N

说明

一般說明

A epimeric lipoxin A₄ (Cat. No. 437720) analog that is more potent and metabolically stable than LXA₄. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.

An epimeric lipoxin A₄ (Cat. No. 437720) analog that is more potent and metabolically stable than LXA₄. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.



Caution! Product contains volatile liquid; keep cold at all times.

Caution! Product contains volatile liquid. Keep product cold at all times.

生化／生理作用

Cell permeable: no

Primary Target
Exhibits anti-inflammatory properties

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Flammable (J)

外觀

In Ethanol.

重構

Following initial thaw aliquot and freeze (-70°C).

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci.24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol.507, 223.
Titos, E., et al. 1999. Am. J. Physiol.277, C870.
Gronert, K., et al. 1998. J. Exp. Med.187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem.272, 6972.
Claria, J., et al. 1996. Mol. Med.2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA92, 9475.
Serhan, C.N., et al. 1995. Biochemistry34, 14609.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H319
• 防範說明: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Flam. Liq. 2
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 55.4 °F
• 閃點（°C）: 13 °C